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Table 4 Interference effects of hemoglobin, bilirubin and lipid (soya bean oil) on CRP measurement performed with the new automated species-specific immunoturbidimetric assay

From: Evaluation of a species-specific C-reactive protein assay for the dog on the ABX Pentra 400 clinical chemistry analyzer

Interferent CRPcontrol [mg/l] ± SD CRPtest [mg/l] ± SD Mean bias [mg/l] % bias % bias < TEdes (29.6%) % bias < TEopt (14.8%)
Hemoglobin 5 g/l 33.7 ± 0.7 34.3 ± 1 0.57 1.7 Yes Yes
Bilirubin 800 mg/l 34.8 ± 0.6 34.9 ± 1 0.13 0.37 Yes Yes
Soy bean emulsion 10 g/l 32.7 ± 0.2 34.4 ± 1 1.63 5.0 Yes Yes
  1. Test samples (CRPtest) with a mean CRP value of 35.5 mg/l spiked with the interfering substances were measured in triplicates and compared to control samples (CRPcontrol) spiked with equal amounts of the diluent used in the test sample. %Bias for the interfering substance was considered acceptable when it was < desired total allowable error (TEdes) and excellent when it was < optimal total allowable error (TEopt) reported previously [32].