Fig. 6From: Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheepWestern immunoblot profile of brains from sheep challenged with caprine scrapie. Lanes 1–6: VV sheep (1: 1418; 2: 1419; 3: 1451; 4: 1452; 5: 1425, 6: 1424); lanes 7–12: LL141 sheep (7: 1319; 8: 1294; 9: 1293; 10: 1286; 11: 1329; 12: 1473); lanes 13–19: LF141 sheep (13: 1320; 14: 1287; 15: 1321; 16: 1302; 17: 1324; 18: 1323; 19: 1322); lanes 20–22: FF141 sheep (20: 1471; 21: 1472; 22: 1476). M: molecular mass markers; C: caprine classical scrapie II142; B: classical BSE; O: ovine classical scrapie (VV). For better visualisation, lanes 2, 3, 6 and controls were cropped from the original blots, indicated by the white boundary lines, to create a composite image. Reactivity with the N-terminal antibody P4 was reduced in LF141 and FF141 sheep, which is unlike classical scrapieBack to article page