Table 1 Patient characteristics, normalized urine S100A8/A9 and S100A12 concentrations, and the urine S100A8/A9-to-S100A12 ratio (uCalR) in all dogs included in the study (n = 239)

Total number

22

40

45

22

35

75

–

Age^c, in years median [IQR]

10.2 ^A [8.6–12.8]

11.1^A [9.5–12.8]

8.8^A [5.9–11.5]

10.0^A [8.0–11.7]

9.4^A [8.4–11.3]

5.5 ^B [3.0–8.8]

<0.0001

Weight^a, in kg median [IQR]

18.2^A [10.9–28.6]

13.7^A [9.8–18.7]

12.7^A [8.3–21.5]

9.8^A [4.8–16.3]

21.8^A [13.7–35.7]

18.1^{b, A} [10.2–26.0]

0.0006

Sex

male/female

9/13

20/20

12/33

9/13

17/18

40/32^b

0.0618

S100A8/A9_USG ^c median [IQR]

438.5 ^A [199.8–8864.1]

196.3^A [67.9–687.0]

310.7^A [44.3–1384.5]

100.8 ^B [28.4–290.1]

23.5 ^B [13.4–97.6]

40.4 ^B [15.3–145.3]

<0.0001

S100A8/A9_Cre ^c median [IQR]

933.6 ^A [353.8–11,600.2]

445.4^A [145.5–1881.4]

956.3^A [151.2–4242.0]

167.8 ^B [42.4–606.6]

53.3 ^B [29.6–225.7]

23.4 ^B [4.5–123.6]

<0.0001

S100A8/A9_Prot ^c Median [IQR]

201.8 ^A [43.6–2541.9]

81.7^A [36.1–259.0]

176.0^A [33.5–637.3]

37.8 ^B [6.7–107.3]

16.4 ^B [5.0–66.7]

151.5^A [69.7–699.7]

<0.0001

S100A12_USG ^c median [IQR]

12.4 ^A [9.1–283.9]

5.0^A [2.6–30.6]

44.5^A [5.0–308.4]

2.8 ^B [1.7–16.8]

1.9 ^B [1.3–3.1]

4.5 ^B [3.0–7.6]

<0.0001

S100A12_Cre ^c median [IQR]

35.2 ^A [14.7–803.6]

12.1 ^B [4.2–61.5]

176.3^A [11.2–1323.1]

4.9 ^B [2.2–44.5]

3.9 ^B [2.7–6.6]

6.1 ^B [4.2–10.5]

<0.0001

S100A12_Prot ^c median [IQR]

7.5 ^A [2.4–44.4]

3.0^A [1.0–12.7]

41.3^A [2.3–129.8]

2.4 ^B [0.5–6.7]

1.6 ^B [0.2–6.4]

10.9^A [5.7–18.4]

<0.0001

uCalR^c median [IQR]

14.7 ^A [10.6–37.7]

29.9^A [7.5–71.1]

6.9 ^B [2.2–14.0]

14.2^A [12.1–36.5]

12.1^A [8.5–30.7]

10.6^A [5.1–26.6]

<0.0001