BMC Veterinary Research

Table 2 Spearman’s rank correlation coefficients between synovial fluid and serum pain mediators and clinical variables of osteoarthritic pain

From: The effect of intra-articular botulinum toxin A on substance P, prostaglandin E₂, and tumor necrosis factor alpha in the canine osteoarthritic joint

Variable	SF PGE₂	Serum PGE₂	SF SP	Serum SP	PVF	VI	HCPI	Pain on palpation
SF PGE₂	1.00	0.23	0.10	−0.05	−0.62*	−0.61*	0.05	0.45*
Serum PGE₂	0.23	1.00	−0.11	−0.48*	0.03	0.04	−0.08	−0.14
SF SP	0.10	−0.11	1.00	0.09	−0.02	0.02	0.02	−0.09
Serum SP	−0.05	−0.48*	0.09	1.00	0.12	0.10	−0.03	−0.04

SF synovial fluid, PGE ₂ prostaglandin E₂, SP substance P, PVF peak vertical force, VI vertical impulse, HCPI Helsinki Chronic Pain Index, Pain on palpation = subjective evaluation of pain on palpation of the joint. *P < 0.05

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ISSN: 1746-6148

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