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Fig. 4 | BMC Veterinary Research

Fig. 4

From: Classical swine fever virus replicated poorly in cells from MxA transgenic pigs

Fig. 4

a. A reduction in the CSFV genome copy number at 96 h post-infection is shown; the copy numbers of CSFV are the means of three repeat experiments. The copy number (viral genomes per nanogram of total RNA) was 1.05 × 105 copies/ng in the control cells, whereas there were 1.89 × 103, 2.31 × 103 and 2.34 × 103 copies/ng in the MxA-positive cells. This result indicates the suppression of CSFV replication in MxA-positive groups. b. Inhibition of virus production in piglet cells. Cells were infected with 100 TCID50 of CSFV for 60 h, and the viral supernatant was diluted and inoculated onto PK-15 cells to assess the TCID50 values from 60 to 120 h. The -logTCID50 values represent the means of three repeat titrations after one time infection at each time point. The data indicate that MxA markedly inhibited infectious virus production for the first 3 days, but thereafter, the extent of the inhibition decreased

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