Effects and synergy of feed ingredients on canine neoplastic cell proliferation

BMC Veterinary Research

Table 2 IC₅₀ of the extracts and chemotherapy determined by MTT assays (single treatment)

	Green tea extract	Pomegranate extract [40 % punicosides]	Rosemary extract [70 % Carnosic Acid]	Turmeric extract	Black pepper extract	Chemotherapy^a
	IC₅₀ (μg/mL)	IC₅₀ (μg/mL)	IC₅₀ (μg/mL)	IC₅₀ (μg/mL)	IC₅₀ (μg/mL)	IC₅₀
C2	11.5	48.5	11.9	4.8	21.8	12.5 nM (6.2 ng mL⁻¹)
CMT-12	20.4	40.9	13.0	9.1	34.5	0.3 μM (163.1 ng mL⁻¹)
D17	47.8	93.8	13.6	12.3	36.5	0.5 μM (271.8 ng mL⁻¹)

Values were determined by averaging duplicate wells in four independent experiments and using Probit analysis
^aC2 treated with toceranib phosphate, CMT-12 and D17 treated with doxorubicin hydrochloride

ISSN: 1746-6148