Study | AED | No of dogs | Prevalence | 95 % CI affected case | Doses of AEDs | Serum levels of AEDs | Treatmentperiod | Body system affected and adverse effects | Most common adverse effects | Adverse effect type |
---|---|---|---|---|---|---|---|---|---|---|
von Klopmann et al. 2007 | Zonisamide as an adjunct to PHB and/or PBr | 11 | 72.7 % | 46.4 %–99.0 % | Zonisamide: mean, 8.9; range, 5–11 mg/kg PO BID PHB and PBr: NA but continued unchanged or reduced if appropriate | Zonisamide: median, 19.2; range, 15.2–38. 4 lg/ml. PHB: median, 121; range, 66–150 5 lmol/l. PBr: median 1.2; range, 0.7–1.7 g/l. | range, 4–17 m | Neurological (ataxia, sedation), ClinPath (increased ALP, ALT and GLDH) | ataxia, sedation, increased ALP | I |
Chung et al. 2012 | Zonisamide | 10 | 10 % | −8.6 %–28.6 % | median 9.5; mean 8.65; range 2.5–12 mg/kg PO BID | range, 15.24–22.41 mg/mL | median, 12; mean, 11.2 m | Neurological (sedation), GI (vomiting, anorexia) | sedation, vomiting, anorexia | I |
Dewey et al. 2004 | Zonisamide as an adjunct to PHB and/or PBr and/or felbamate and/or gaba and/or cloraz | 12 | 50 % | 21.7 %–78.3 % | Zonisamide: mean, 8.9; range, 5–11 mg/kg PO BID. Other AEDs: NA but in 9/12 dogs concurrent AEDs doses were eliminated or reduced. | Zonisamide: median, 23.5; mean, 21.2 μg/mL. | mean, 8; median, 9; range, 2–18 m | Neurological (ataxia, sedation), GI (vomiting), ClinPath (ALP) | ataxia, increased ALP | I |
Walker et al. 1988 | Zonisamide | 40 | NA | NA | 10, 30 or 75 mg/kg PO SID | range, 10–140 ug/ml | 13 m | Neurological (aggression) GI (emaciation), ClinPath (increased ALP, decreased albumin) | aggression, increased ALP, decreased albumin | I |
Boothe et al. 2008 | Zonisamide | 8 | 0 % | 0 % | 6.9 mg/kg IV SID or 10.3 mg⁄kg PO SID | range, 6–55 mcg⁄ml | 2 m | Endocrine (Decreased total T4) (However, total T4 was only slightly decreased at the study end) | NA | I |
Cook et al. 2011 | Zonisamide | 1 | NA | NA | range, 7.9–8.4 mg/kg PO BID | 38 μg/mL | 18 m | ClinPath (mixed acid base disorder) | NA | II |
Miller et al. 2011 | Zonisamide | 1 | NA | NA | 7.7 mg/kg PO BID | NA | 0.3 m | GI (hepatoxicity) | NA | II |