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Table 3 Comparison of observed and expected numbers of scrapie positive samples for each amino acid variant. Allele frequencies of the pre-exposed herd are indicated in parentheses. P-values of <0.05 are indicated in bold. Chi-square analysis was used for herd 1, and Fisher’s exact test was used for herd 2 as the sample size was low

From: Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats

  

Numbers in Scrapie positive samples

  

Herd #1

Herd #2

Codon

Genotype

Observed

Expected≠

Observed

Expected≠

142

II (0.915)

54

51

10

8

IM (0.085)

0

3

0

2

MM (0.000)

0

0

0

0

143

HH (0.997)

53

54

10

10

HR (0.000)

0

0

0

0

RR (0.003)

1

0

0

0

146

NN (0.876)

54

49

10

8

NS (0.105)

0

5

0

2

SS (0.019)

0

1

0

0

211

RR (0.615)

52

30

10

8

RQ (0.333)

2

20

0

2

QQ (0.051)

0

4

0

0

222

QQ (0.969)

54

52

10

10

QK (0.021)

0

2

0

0

KK (0.010)

0

1

0

0

240

PP (0.295)

16

12

3

5

PS (0.465)

30

28

7

3

SS (0.239)

8

15

0

2

  1. ≠Allele frequencies for the expected numbers were calculated using the frequencies of the pre-exposed herd