Fig. 5From: Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumoursSG2000-induced anti-tumour activity in LMeC (a,b) or CMeC-1 (c,d) canine melanoma tumour xenografts in CD1 Nu/Nu nude mice. a and c are with a single dose of SG2000 i.v. at 0.15 mg/kg or 0.30 mg/kg compared to vehicle only controls. Median tumour volume (cm3) from six mice per group is plotted against time in days. b and d are as in a and c but SG2000 is given one dose per week for three weeks i.v. at 0.15 mg/kg [●] or 0.30 mg/kg [♦]Back to article page