BMC Veterinary Research

Table 1 Haematology and biochemistry in horses with pythiosis treated by IRLP with amphotericin B and DMSO. Mean values of haematology and selected blood biochemistry tests before (week 0) and after (1 to 9 weeks) intravenous regional perfusion with amphotericin B in a 10 % DMSO solution in 15 horses with pythiosis

From: Evaluation of intravenous regional perfusion with amphotericin B and dimethylsulfoxide to treat horses for pythiosis of a limb

	Haematology					Biochemistry
Weeks	RBC (x10⁶/μL)	PCV* (%)	TLC* (x10³/μL)	SN* (x10³/μL)	E* (/μL)	Fibrinogen (g/L)	TP (g/L)	AST (UI/L)	GGT (UI/L)	ALP (UI/L)	CR* (μmol/L)	U (mmol/L)
0	6.17	26^ab	21^a	15.38^a	949.83^a	5.2	74^d	192^d	17.30^d	306.53^d	112.27^ad	13.24^d
1	5.54	24^a	14.32^ab	10.15^ab	827.20^ab	4.6	75^d	163^d	20.78^d	213.33^d	74.26^bd	13.02^d
2	6.65^d	28^ab	11.54^bcd	7.41^bcd	577.43^abd	4^d	77^d	167^d	18.49^d	254.12^d	79.56^bd	14.40^d
3	6.74^d	29^ab	10.77^bcd	6.24^bcd	571.83^abd	3.7^d	75^d	181^d	15.38^d	222.53^d	79.56^bd	13.97^d
4	7.25^d	31^b	10.48^bcd	5.98^bcd	438.33^abd	2^d	75^d	194^d	13.77^d	273.51^d	78.68^bd	16.25^d
5	7.45^d	31^b	9.28^bcd	5.32^bcd	346.67^abd	2.7^d	72^d	214^d	15.94^d	268.19^d	80.44^bd	17.04^d
6	7.34^d	32^bd	8.67^bcd	4.55^cd	334.17^abd	3^d	72^d	184^d	17.85^d	210.73^d	80.44^bd	18.58^d
7	7.38^d	31^b	8.38^cd	5.04^bcd	287.17^bd	2^d	72^d	196^d	14.17^d	211.73^d	94.59^abd	17.83^d
8	7.80^d	33^bd	9.13^bcd	5.06^bcd	315^abd	2^d	72^d	195^d	14.40^d	200.18^d	84.86^abd	13.54^d
9	7.66^d	32^abd	9.13^bcd	5.41^bcd	189^abd	2^d	69^d	221^d	13.80^d	277.28^d	83.98^abd	13.05^d
Reference range²²	6.4–10.0	32–47	5.2–13.9	2.26–8.58	0–600	1–4	57–79	152–294	9–25	143–395	88.4–167.96	9.21–19.96

RBC red blood cell count, PCV packed cell volume, TLC total leukocytic count, SN segmented neutrophils, E eosinophils, F fibrinogen, TP total protein, AST aspartate aminotransferase, GGT gamma-glutamyltransferase, ALP alkaline phosphatase, CR creatinine, U urea nitrogen
*Significant at probability ≤ 0.05
^a; ^b; ^c - means with different letters are significantly different (Tukey’s test; P ≤ 0.05); d Mean value inside reference range

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ISSN: 1746-6148

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