Fig. 3

Hippocampal changes in a 22 month male neutered Oriental Shorthair with drug-resitant epilepsy. Images obtained in a 1.5 T MRI (Siemens Symphony, Erlangen, Germany) 12 months after the images in Fig. 2. Despite an initial course of corticosteroids and polypharmacy with multiple anti-convulsants the cat seizured on an almost daily basis. a Dorsal T2W orientated perpendicular to long axis of the hippocampus. b Transverse T2W orientated parallel to the long axis of the hippocampus. c Dorsal FLAIR orientated perpendicular to long axis of the hippocampus. d Transverse FLAIR orientated to long axis of the hippocampus. e Dorsal T1W 3D images 1 mm slice thickness orientated perpendicular to long axis of the hippocampus. f Dorsal T1W orientated perpendicular to long axis of the hippocampus post gadolinium. On FLAIR and T2W images there is reduction in volume and a hyperintensity of the hippocampus (yellow arrows). With the TIW 3D images it is possible to appreciate loss in definition between the white and grey matter in addition to reduction in volume of the hippocampus (blue arrow) There is no abnormal enhancement with gadolinium contrast