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Table 3 Micro-CT results

From: Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model

 

CTRL

OA

CTRL + DC

OA + DC

 

mean ± std.dev

mean ± std.dev

mean ± std.dev

mean ± std.dev

Subchondral bone microstructure

BV/TV (%)

48.46 ± 7.74c

49.37 ± 4.38

56.34 ± 2.96a

51.92 ± 4.99

Tb.Th (μm)

265.21 ± 32.62

288.75 ± 60.43

283.20 ± 34.22

281.18 ± 56.18

Tb.Sp (μm)

467.24 ± 122.46c

423.12 ± 66.21

354.74 ± 36.25a

433.27 ± 54.03

Tb.N (mm−1)

1.83 ± 0.20

1.76 ± 0.29

2.01 ± 0.23

1.89 ± 0.30

Tb.Pf (mm−1)

−3.27 ± 1.49

−3.24 ± 0.51

−4.16 ± 1.54

−4.01 ± 1.15

SMI

−0.66 ± 0.47

−0.72 ± 0.39

−1.07 ± 0.48

−0.96 ± 0.60

DA

0.71 ± 0.06c,d

0.69 ± 0.06c,d

0.57 ± 0.09a,b

0.57 ± 0.06a,b

Volumetric subchondral bone mineral density

vBMD (mg/cm3)

505.90 ± 98.53

512.78 ± 52.52c

608.36 ± 24.43b

548.69 ± 58.95

Cartilage morphology

nCg.Th (μm)

309.06 ± 62.99b

494.80 ± 169.59a,c,d

269.01 ± 39.93b

359.75 ± 48.62b

nCg.V (mm3)

3.37 ± 0.78b

5.69 ± 2.72a,c

2.81 ± 0.52b

3.71 ± 0.50

  1. Mean values ± standard deviation of the micro-CT parameters obtained for all experimental groups. All variables showed a normal distribution, and only vBMD showed no homogeneity of variances. Statistical significance p < 0.05: a vs. CTRL; b vs. OA; c vs. CTRL + DC; d vs. OA + DC