Dynamic expression of leukocyte innate immune genes in whole blood from horses with lipopolysaccharide-induced acute systemic inflammation

Table 2 Evaluation of the overall post-induction expression levels compared with pre-induction levels at PIH 0

All genes	2A: Genes with statistically significant differential expression	2B: Genes with statistically significant differential expression ≥ 2.5 fold	2C: Genes with statistically significant up-regulation ≥ 2.5 fold	2D: Genes with statistically significant down-regulation ≥ 2.5 fold	2E: Genes with statistically significant mixed up- and down-regulation ≥ 2.5 fold
IL1B	IL1B	IL1B	IL1B
IL1RN	IL1RN	IL1RN	IL1RN
IL2
IL4	IL4
IL6	IL6	IL6	IL6
IL6ST	IL6ST	IL6ST	IL6ST
IL8	IL8	IL8	IL8
IL10	IL10	IL10	IL10
IL15	IL15	IL15		IL15
IL17	IL17	IL17			IL17
IL18	IL18	IL18			IL18
TNF	TNF	TNF	TNF
TLR4	TLR4	TLR4	TLR4
TLR9	TLR9
SELL	SELL	SELL			SELL
ITGAM	ITGAM	ITGAM	ITGAM
ITGAX	ITGAX	ITGAX	ITGAX
TGFB1	TGFB1
HMGB1	HMGB1
MIF	MIF
CD14	CD14	CD14			CD14
NKAP	NKAP
MAPK14	MAPK14	MAPK14			MAPK14
FAS	FAS
BID	BID
CASP3	CASP3	CASP3			CASP3
BCL2L1	BCL2L1	BCL2L1	BCL2L1
MMP8	MMP8	MMP8	MMP8
TIMP1	TIMP1	TIMP1	TIMP1
CCL5	CCL5	CCL5		CCL5
SOD2	SOD2	SOD2			SOD2

2A: genes with a statistically significant differential expression at minimum one time point after LPS-induction. 2B: genes with statistically significant differential expression of at least 2.5 fold. 2C, 2D, and 2E: genes with statistically significant up-regulation, down-regulation, and mixed up- and down-regulation, respectively, of at least 2.5 fold. All genes listed in 2A – 2E had p-values below 0.0001

ISSN: 1746-6148