Parameters | Sheep | Goats | ||
---|---|---|---|---|
5 mg/kg | 5 mg/kg | 10 mg/kg | 15 mg/kg | |
T1/2λz (h) | 4.57 ± 2.36* | 1.92 ± 0.37 | 2.72 ± 0.88 | 2.43 ± 0.47 |
Tmax (h) | 18.50 ± 4.75 | 17.14 ± 5.52& | 25.14 ± 3.02 | 26.00 ± 5.66 |
Cmax (μg/mL) | 0.53 ± 0.10 | 0.68 ± 0.25& | 1.41 ± 0.20 | 1.75 ± 0.26 |
Tlast (h) | 42.00 ± 8.28* | 30.86 ± 3.02 | 41.14 ± 8.55 | 46.00 ± 5.66 |
AUClast (μg.h/mL) | 12.34 ± 3.82 | 11.43 ± 3.20& | 30.52 ± 6.84¥ | 41.96 ± 6.55 |
MRTlast (h) | 19.78 ± 3.42 | 16.16 ± 2.05 | 20.74 ± 3.02 | 20.79 ± 2.23 |
Cmax (μg/mL) (Normalized)# | 0.53 ± 0.10 | 0.68 ± 0.25 | 0.70 ± 0.10 | 0.58 ± 0.08 |
AUC (μg.h/mL) (Normalized)# | 12.34 ± 3.82 | 11.43 ± 3.20 | 15.26 ± 3.42 | 13.98 ± 2.18 |