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Table 5 Comparative mean (±SD) kinetic parameters of ABZ-SO2 in goats and sheep following subcutaneous administrations of ABZ-SO at a dose rate of 5 mg/kg and at increased dose rates (10 and 15 mg/kg) in goats (n = 8)

From: Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats

Parameters

Sheep

Goats

5 mg/kg

5 mg/kg

10 mg/kg

15 mg/kg

T1/2λz (h)

4.57 ± 2.36*

1.92 ± 0.37

2.72 ± 0.88

2.43 ± 0.47

Tmax (h)

18.50 ± 4.75

17.14 ± 5.52&

25.14 ± 3.02

26.00 ± 5.66

Cmax (μg/mL)

0.53 ± 0.10

0.68 ± 0.25&

1.41 ± 0.20

1.75 ± 0.26

Tlast (h)

42.00 ± 8.28*

30.86 ± 3.02

41.14 ± 8.55

46.00 ± 5.66

AUClast (μg.h/mL)

12.34 ± 3.82

11.43 ± 3.20&

30.52 ± 6.84¥

41.96 ± 6.55

MRTlast (h)

19.78 ± 3.42

16.16 ± 2.05

20.74 ± 3.02

20.79 ± 2.23

Cmax (μg/mL) (Normalized)#

0.53 ± 0.10

0.68 ± 0.25

0.70 ± 0.10

0.58 ± 0.08

AUC (μg.h/mL) (Normalized)#

12.34 ± 3.82

11.43 ± 3.20

15.26 ± 3.42

13.98 ± 2.18

  1. T 1/2λz terminal half-life; T max time to reach peak plasma concentration; C max peak plasma concentration; T last time to last detectable plasma concentration; AUC last area under the (zero moment) curve from time 0 to the last detectable concentration; MRT last mean residence time
  2. *The parameters in sheep are significantly different from those in goats (*P < 0.05)
  3. #AUC and Cmax values were dose-normalized dividing the observed value by 2 (10 mg/kg) or 3 (15 mg/kg)
  4. &The parameters in goats observed after a dose of 5 mg/kg are significantly different from those in goats observed after doses of 10 and 15 mg/kg (&P < 0.05)
  5. ¥The parameters in goats observed after a dose of 10 mg/kg are significantly different from those in goats observed after a dose of 15 mg/kg (&P < 0.05)