Parameters | Goat | Sheep | ||
---|---|---|---|---|
(−) ABZ-SO | (+) ABZ-SO | (−) ABZ-SO | (+) ABZ-SO | |
T1/2λz (h) | 3.66 ± 0.66* | 8.03 ± 1.67 | 3.98 ± 0.64* | 9.36 ± 2.23 |
Cmax (μg/mL) | 2.32 ± 0.40 | 2.11 ± 0.33 | 2.33 ± 0.27 | 1.95 ± 0.29 |
Tlast (h) | 15.43 ± 1.51* | 20.57 ± 4.28 | 17.00 ± 2.83* | 30.00 ± 3.70 |
AUClast (μg.h/mL) | 11.73 ± 2.43* | 18.45 ± 5.62 | 11.96 ± 1.50* | 20.53 ± 3.90 |
AUCMlast (μg.s2/mL) | 51.33 ± 16.00 | 135.35 ± 62.98 | 55.53 ± 9.48* | 186.82 ± 49.46 |
Cl (L/h/kg) | 0.42 ± 0.10* | 0.24 ± 0.06 | 0.40 ± 0.06 | 0.24 ± 0.06 |
MRTlast (h) | 4.29 ± 0.57* | 7.07 ± 1.20 | 4.63 ± 0.38* | 8.98 ± 1.44 |
Vdss (L/kg) | 2.05 ± 0.24 | 2.53 ± 0.41 | 2.23 ± 0.27 | 2.47 ± 0.30 |