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Figure 3 | BMC Veterinary Research

Figure 3

From: Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome

Figure 3

Light and electron microscopy of affected (a&c) and unaffected (b&d) skin. Light microscopy of affected (a) and unaffected (b) skin: The deep dermis is markedly thinned (approximately 30% of dermal thickness of hind limb skin of unaffected 1-day-old control Warmblood foal (b)) and shows a reduced number of thin, irregular collagen bundles separated by clear spaces. The epidermis and adnexal structures appear normal. Subcutaneous tissue was detached from the overlying dermis and is missing on this slide. The size bars indicate 200Ā Ī¼m. Haematoxylin and eosin staining (HE), 4x. Electron microscopy of affected (c) and unaffected (d) skin: In the affected skin (c) (front limb) a mild randomness in orientation and variability of the cross-sections of the collagen fibrils are present. The size bar indicates 0.5Ā Ī¼m. The skin of the control (d) (hind limb from a 1-day-old control Warmblood foal) shows regular orientation of collagen fibrils with no visible variability of cross-sections. The size bar indicates 1Ā Ī¼m.

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