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Table 2 Ketamine-Xylazine– mean values with standard deviation

From: Influence of repeated anaesthesia on physiological parameters in male Wistar rats: a telemetric study about isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl

Parameter

Run

Baseline

Induction

Non-surgical tolerance

Recovery

 

(No. of animals)

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

SAP (mmHg)

1 (6)

116 ± 11.27

130 ± 12.81

96 ± 12.38

104 ± 9.16

2 (6)

118 ± 11.85

133 ± 13.38

97 ± 7.07

106 ± 8.86

3 (6)

114 ± 7.93

134 ± 11.38

96 ± 10.78

106 ± 6.18

4 (6)

116 ± 10.03

138 ± 10.86*

95 ± 9.36

105 ± 6.09

5 (6)

115 ± 9.65

133 ± 6.83

100 ± 9.89

103 ± 5.40

6 (5)

115 ± 6.14

138 ± 6.62

102 ± 6.18

105 ± 4.85

DAP (mmHg)

1 (6)

85 ± 9.85

96 ± 9.39

68 ± 10.01

76 ± 6.38

2 (6)

88 ± 10.40

96 ± 13.27

69 ± 7.57

77 ± 8.68

3 (6)

86 ± 10.10

103 ± 7.13

69 ± 9.81

78 ± 6.66

4 (6)

87 ± 8.15

103 ± 8.76

69 ± 7.13

75 ± 2.87

5 (6)

86 ± 7.04

99 ± 7.09

72 ± 9.14

75 ± 2.57

6 (5)

84 ± 5.83

102 ± 6.44

71 ± 5.24*

74 ± 1.39

MAP (mmHg)

1 (6)

95 ± 10.13

108 ± 10.35

77 ± 10.65

85 ± 7.08

2 (6)

98 ± 10.40

108 ± 12.93

79 ± 6.68

87 ± 8.34

3 (6)

95 ± 8.86

113 ± 8.12

78 ± 9.29

87 ± 5.76

4 (6)

96 ± 8.40

115 ± 9.05

78 ± 6.92

85 ± 3.64

5 (6)

96 ± 7.24

110 ± 6.16

81 ± 8.42

84 ± 2.20

6 (5)

95 ± 5.50

114 ± 6.35

81 ± 5.07

85 ± 2.39

PP (mmHg)

1 (6)

31 ± 4.42

34 ± 5.40

28 ± 4.52

28 ± 4.74

2 (6)

30 ± 6.95

36 ± 6.67*

28 ± 6.76

29 ± 5.51

3 (6)

28 ± 6.89

32 ± 7.08

27 ± 8.65

27 ± 6.39

4 (6)

30 ± 5.73

35 ± 6.20*

27 ± 8.29

30 ± 4.57*

5 (6)

29 ± 7.22

33 ± 7.09

28 ± 8.86

28 ± 6.47

6 (5)

31 ± 4.71

36 ± 2.97

31 ± 4.91

31 ± 3.94*

HR (bpm)

1 (6)

283 ± 36.14

354 ± 38.00

273 ± 23.56

288 ± 19.35

2 (6)

284 ± 20.10

375 ± 45.16

281 ± 20.12

292 ± 12.37

3 (6)

278 ± 14.31

359 ± 33.95

273 ± 19.86

296 ± 21.69

4 (6)

281 ± 22.22

340 ± 28.56

275 ± 35.47

290 ± 27.95

5 (6)

285 ± 20.98

362 ± 31.88

275 ± 29.33

292 ± 13.50

6 (5)

282 ± 21.89

362 ± 10.24

269 ± 21.50

277 ± 18.54

BT (°C)

1 (6)

37.39 ± 0.59

37.34 ± 0.63

36.96 ± 0.48

37.57 ± 0.47

2 (6)

37.49 ± 0.27

37.44 ± 0.22

37.34 ± 0.32*

37.79 ± 0.32

3 (6)

37.42 ± 0.19

37.27 ± 0.24

37.18 ± 0.37

37.72 ± 0.31

4 (6)

37.59 ± 0.23

37.40 ± 0.26

37.35 ± 0.45*

37.54 ± 0.53

5 (6)

37.56 ± 0.37

37.55 ± 0.39

37.46 ± 0.45*

37.79 ± 0.32

6 (5)

37.73 ± 0.48

37.58 ± 0.58

37.43 ± 0.36*

37.79 ± 0.08

  1. *Statistical significant difference (p value ≤ 0.05) based on the ANCOVA with baseline as covariate for the comparison of anaesthetic stages between run 2–6 versus run 1.
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BMC Veterinary Research

ISSN: 1746-6148

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