Table 2 Effects of HPTP on liver functions in rats (male and female) in acute toxicity studies
Animals | T. protein (g/L) | Albumin (g/L) | Globulin (g/L) | T. billirubin (μmol/L) | ALP (IU/L) | ALT (IU/L) | AST (IU/L) |
|---|---|---|---|---|---|---|---|
Male | |||||||
CMC 0.5% | 58.5 ± 2.50 | 14.0 ± 0.8 | 45.0 ± 2.0 | 3.3 ± 0.3 | 97.5 ± 3.6 | 55.8 ± 1.5 | 171.0 ± 5.5 |
250 mg/kg | 53.0 ± 2.6 | 13.3 ± 1.4 | 47.5 ± 2.8 | 4.3 ± 0.5 | 87.0 ± 8.3 | 46.5 ± 2.2 | 183.5 ± 11.2 |
500 mg/kg | 55.8 ± 0.9 | 14.8 ± 0.6 | 54.8 ± 2.7 | 3.3 ± 0.3 | 101.3 ± 8.1 | 56.3 ± 3.7 | 189.3 ± 6.8 |
1000 mg/kg | 55.8 ± 1.1 | 14.8 ± 1.1 | 52.8 ± 3.1 | 4.0 ± 0.4 | 105.5 ± 6.7 | 59.3 ± 4.9 | 176.3 ± 14.5 |
Female | |||||||
CMC 0.5% | 59.8 ± 1.8 | 13.0 ± 0.4 | 42.5 ± 0.9 | 3.5 ± 0.3 | 87.5 ± 1.9 | 55.3 ± 2.8 | 170.0 ± 4.3 |
250 mg/kg | 58.5 ± 2.5 | 12.8 ± 1.0 | 48.0 ± 1.8 | 4.0 ± 0.4 | 85.0 ± 3.9 | 56.0 ± 3.9 | 189.5 ± 12.7 |
500 mg/kg | 55.0 ± 2.1 | 15.3 ± 0.6 | 50.8 ± 3.7 | 3.8 ± 0.5 | 93.0 ± 6.4 | 54.8 ± 2.7 | 194.5 ± 11.7 |
1000 mg/kg | 55.5 ± 2.3 | 15.3 ± 0.8 | 49.0 ± 2.8 | 3.8 ± 0.5 | 104.3 ± 4.3 | 60.0 ± 4.2 | 215.8 ± 13.0 |