Table 1 Carprofen concentrations of plasma samples Group 3 (VECA)

Day 0 (1 day prior surgery)

-

-

15 min. after 1^st application (day 0)

-

-

20 min. after 1^st application (day 0)

-

-

30 min. after 1^st application (day 0)

<2.0

-

1 h after 1^st application (day 0)

2.6

<2.0

2 h after 1^st application (day 0)

5.5

4.1

3 h after 1^st application (day 0)

7.2

7.7

6 h after 1^st application (day 0)

19.1

16.8

18 h after 1^st application (day 1)

72.0

54.1

Intra OP (day 1)

61.0

57.1

5 min. prior to 2^nd application (day 3)

35.4

38.0

15 min. after 2^nd application (day 3)

34.3

34.6

20 min. after 2^nd application (day 3)

33.8

35.4

30 min. after 2^nd application (day 3)

34.8

35.5

1 h after 2^nd application (day 3)

33.8

36.2

2 h after 2^nd application (day 3)

41.2

42.1

3 h after 2^nd application (day 3)

46.8

46.4

6 h after 2^nd application (day 3)

104

105

18 h after 2^nd application (day 4)

187

325

6 h after application (week 1)

416

456

6 h after application (week 2)

419

347

6 h after application (week 3)

402

479

6 h after application (week 4)

301

376

6 h after application (week 5)

203

412

6 h after application (week 6)

343

675

1 week after the last application (week 7)

63.4

163