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Table 7 Details of numbers of dogs, pre- and post- treatment seizure frequency, period of treatment, doses of AED(s), seizure frequency reduction/response after the initiation of treatment and efficacy statements for each study

From: Treatment in canine epilepsy – a systematic review

References

Schwartz-Porsche et al.[30]

Schwartz-Porsche et al.[15]

Cunningham et al.[29]

Löscher et al.[26]

Rieck et al.[27]

Morton et al.[31]

AED evaluated

Primidone

2 nd AED

-

-

-

-

-

3 rd AED

-

-

-

-

-

4 th AED

-

-

-

-

-

No of dogs

30

20

15

26

12

Period of treatment (months)

Approx. 6

mean, 14; range, 6.0-35

9

mean, 6.0 ± 0.6

Unclear

Dose of AED(s) (mg/kg)

range, 13–100 PO SID

range, 17–107 PO SID

NA

mean, 51; range 24–70 PO SID

median, 50; mean, 48; range, 18–94 PO SID

Pre-treatment SF (seizures/month)

NA

NA

NA

mean, 1.75 (over a period of 9 m)

median, 8; mean, 8.5; range, 0–20 (period was not reported)

Post-treatment SF (seizures/month)

NA

NA

NA

mean, 0.59

median, 0; mean 0.83; range, 0-8

No of dogs that were failures

5/30 (17%)

8/20 (40%)

2/15 (13%)

7/26 (27%)

-

No of dogs with >0% - <50% reduction in SF

5/30 (17%)

-

-

-

2/12 (17%)

No of dogs with ≥50% - <100% reduction in SF

10/30 (33%)

7/20 (35%)

6/15 (40%)

16/26 (62%)

-

No of dogs with 100% reduction in SF

10/30 (33%)

5/20 (25%)

7/15 (47%)

4/26 (15%)

10/12 (83%)

No of dogs with >30% reduction in SF

20/30 (67%)

12/20 (60%)

13/15 (87%)

20/26 (77%)

11/12 (92%)

95% CI successfully treated cases

50% - 83%

39% - 81%

70% - 100%

61% - 93%

62% - 100%

Overall evidence for/against recommending the use of an AED

Insufficient evidence for recommending the use of primidone as a monotherapy AED

  1. AED(s), anti-epileptic drug(s); BID, bis in die (twice daily); Chloraz, Chlorazepate; CSF, cerebrospinal fluid; CL, confidence level; Diaz, Diazepam; Gaba, Gabapentin; IE, idiopathic epilepsy; LEV, Levetiracetam; m, month(s); NA, Not Available; PB, phenobarbital; PBr, potassium bromide; PO, per os; SF, seizure frequency; SID, semel in die (once daily); TID, ter in die (three times daily); TPM, Topiramate; w, week(s).