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Table 2 MMP-9, MMP-2, MT1-MMP, TIMP-1, TIMP-2, VEGF-A, VEGF-164 and RECK mRNA expression in control lymph nodes, B-cell and T-cell lymphomas, CLBL-1 and OSW lymphoma cell lines

From: The role of vascular endothelial growth factor and matrix metalloproteinases in canine lymphoma: in vivo and in vitro study

Genes

Control lymph nodes

B-cell lymphoma

T-cell lymphoma

CLBL-1

OSW

MMP-2

0.96 ± 0.23a,b

0.24 ± 0.28

0.16 ± 0.29

0.00

0.00

TIMP-2

0.85 ± 0.34a,b

0.15 ± 0.20

0.16 ± 0.29

0.00

0.82

MT1-MMP

0.61 ± 0.17a

0.11 ± 0.11c

0.94 ± 0.99

0.04

4.11

MMP-9

0.13 ± 0.11b

0.12 ± 0.04 c

0.69 ± 0.11

0.76

1128.35

TIMP-1

0.15 ± 0.09b

0.16 ± 0.22 c

0.66 ± 0.75

0.72

2.38

RECK

0.29 ± 0.12b

0.06 ± 0.12c

0.87 ± 1.12

4.32

19.56

VEGF-A

0.37 ± 0.19b

0.71 ± 0.98

0.89 ± 1.37

4.87

1.42

VEGF-164

0.57 ± 0.23

0.63 ± 0.92

0.90 ± 1.38

7.99

3.18

  1. Data are expressed as relative quantification values (arbitrary units, mean ± SD).
  2. a, b, c Significant differences between control lymph nodes and B-cell lymphoma, control lymph nodes and T-cell lymphoma, B-cell lymphoma and T-cell lymphoma, respectively (Kruskal-Wallis test followed by Dunn’s post test; p < 0.05).