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Table 1 Survival times of tg a 20 mice inoculated intracranially with serially diluted or treated RML brain homogenate

From: Exposure of RML scrapie agent to a sodium percarbonate-based product and sodium dodecyl sulfate renders PrPScprotease sensitive but does not eliminate infectivity

Dilution or treatment

Mean survival time in days ± SD (% survival)

1) RML titration series *

100

65.5 ± 3.4 (0%)

10-1

73.6 ± 3.3 (0%)

10-2

83.2 ± 6.1 (0%)

10-3

195.4 ± 148.5 (22%)

10-4

394.8 ± 120.3 (78%)

10-5 through 10-12

455 (100%) – study termination

2) Treated RML

SPC-PL x 30 min

67.1 ± 2.6 (0%)

SPC-PL x 90 min

68.8 ± 4.6 (0%)

SPC-PL x 180 min

68.5 ± 2.8 (0%)

SPC-PH x 30 min

70.3 ± 6.0 (0%)

SPC-PH x 90 min

71.0 ± 5.1 (0%)

SPC-PH x 180 min

73.8 ± 3.2 (0%)

SPC-PL + SDS x 30 min

93 ± 9.7 (0%)

SPC-PL + SDS x 90 min

136.4 ± 72.2 (10%)

SPC-PL + SDS x 180 min

178.7 ± 92.4 (20%)

SPC-PH + SDS x 30 min

92.5 ± 7.6 (0%)

SPC-PH + SDS x 90 min

86.4 ± 6.9 (0%)

SPC-PH + SDS x 180 min

84.7 ± 11.1 (0%)

SDS x 30 min

84.9 ± 12.3 (0%)

SDS x 90 min

107.5 ± 40.5 (0%)

SDS x 180 min

85.7 ± 6.7 (0%)

  1. Abbreviations: SD, standard deviation; SPC-P L or H , low or high concentration sodium percarbonate-based product; SDS, sodium dodecyl sulfate.
  2. *1% w/v starting (100) concentration.