Figure 4
Effect of SPC-P with or without SDS on infectivity. Kaplan-Meier survival curves were generated to compare SPC-P treatment conditions with 10-fold serial dilutions of RML scrapie in tga20 mice. A) Treatment with SPC-PL or SPC-PH alone had minimal effect on infectivity with 0% survival. B) Combining SPC-P and SDS resulted in 2–3 log10 reductions in infectivity depending on treatment condition. Greater reductions and higher survival percentages were observed with the SPC-PL + SDS groups in a time-dependent manner. Exposure to SDS alone resulted in an approximate 2 log10 reduction in infectivity (combined data from 30 min., 90 min., and 180 min. exposure groups). Abbreviations: SPC-PL or H, low or high concentration sodium percarbonate-based product; SDS, sodium dodecyl sulfate.