Table 4 Multivariate Cox proportional hazard analysis of clinicopathologic variables for ovarall survival rate
From: Expression of autophagy-related protein beclin-1 in malignant canine mammary tumors
Multivariate analysis | |||
|---|---|---|---|
Hazard ratio | 95% confidence interval | p value | |
Age (> 11 years vs. ≦ 11 years) | 1.460 | 0.683 - 3.124 | 0.329 |
Tumor size (> 3 cm vs. ≦ 3 cm) | 3.038 | 1.298 - 7.108 | 0.010* |
Tubular formation (> 10% vs. ≦ 10%) | 0.364 | 0.167 - 0.794 | 0.011* |
Nuclear pleomorphism (high vs. low) | 1.001 | 0.445 - 2.253 | 0.997 |
Mitotic count (> 11 vs. ≦ 10/10 HPFs) | 0.881 | 0.166 - 4.676 | 0.882 |
Histologic grade (3 vs. 2 and 1) | 0.627 | 0.088 - 4.486 | 0.642 |
Lymphovascular invasion (yes vs. no) | 2.286 | 0.887 - 5.887 | 0.087 |
Necrosis (extensive vs. limited/no) | 0.977 | 0.473 - 2.019 | 0.951 |
Estrogen receptor (negative vs. positive) | 0.499 | 0.232 - 1.076 | 0.076 |
Her2/neu overexpression (positive vs. negative) | 2.433 | 0.950 - 6.234 | 0.064 |
Beclin-1 cytoplasmic expression (low vs. high) | 2.752 | 1.211 - 6.256 | 0.016* |
Beclin-1 nuclear expression (low vs. high) | 1.471 | 0.667 - 3.243 | 0.339 |