Table 3 Performance characteristics of best variables for diagnosis of fatty liver
From: Serum paraoxonase-1 as biomarker for improved diagnosis of fatty liver in dairy cows
Test/panel of tests | Sensitivity | Specificity | PPV | NPV | +LR | –LR | DOR | Accuracy | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
% | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI | Â | 95% CI | Â | 95% CI | Â | 95% CI | % | |
PON | 86.7 | 75.7–94.2 | 93.5 | 80.9 –97.5 | 92.8 | 81.0–98.3 | 87.7 | 72.5–94.4 | 12.2 | 4.1–36.7 | 0.1 | 0.0–0.2 | 93.1 | 21.8 –398.0 | 90.1 |
NEFA | 92.8 | 81.3 –97.6 | 86.9 | 72.5–98.1 | 86.6 | 73.0–94.5 | 92.0 | 79.4–98.1 | 6.9 | 3.2–14.7 | 0.0 | 0.0–0.2 | 86.6 | 20.2–371.0 | 89.7 |
NEFA+PON | 99.7 | 89.6–99.8 | 95.2 | 83.0–99.1 | 95.4 | 83.7–99.1 | 99.7 | 89.2–99.8 | 21.0 | 5.6–78.6 | 0.0 | 0.0 –1.1 | 8440.0 | 14.6–4871511.6 | 97.7 |
NEFA+BHBA | 92.8 | 81.3–97.6 | 90.9 | 77.4–96.1 | 90.6 | 77.4–97.0 | 93.0 | 79.4–98.1 | 9.5 | 3.7–24.2 | 0.0 | 0.0 – 0.2 | 123.3 | 25.8–588.2 | 91.8 |
NEFA+BHBA+PON | 97.6 | 87.9–99.5 | 95.4 | 83.8–98.6 | 95.3 | 83.3–99.2 | 97.6 | 85.9–99.8 | 20.0 | 5.1–77.4 | 0.0 | 0.0–0.1 | 819.0 | 71.4–9393.6 | 96.5 |
NEFA+BHBA+AST | 92.5 | 79.0–98.1 | 90.2 | 75.9–96.8 | 90.2 | 77.4–97.0 | 93.0 | 78.5–98.0 | 9.7 | 3.8–24.7 | 0.0 | 0.0–0.2 | 166.5 | 28.6–966.1 | 91.6 |
NEFA+BHBA+AST+PON | 97.5 | 86.8–99.5 | 95.4 | 83.5–98.6 | 95.1 | 83.3–99.2 | 97.6 | 85.2–99.8 | 19.4 | 5.0–75.3 | 0.0 | 0.0–0.1 | 722.0 | 62.7–8301.8 | 96.4 |
NEFA+BHBA+AST+LCAT | 94.8 | 82.7–98.5 | 90.0 | 77.4–96.1 | 90.2 | 75.4–96.7 | 94.7 | 81.3–99.1 | 9.7 | 3.8–24.7 | 0.0 | 0.0–0.2 | 166.5 | 28.6–966.1 | 92.4 |
NEFA+BHBA+AST+LCAT+PON | 97.4 | 86.8-99.5 | 95.0 | 83.5–98.6 | 95.0 | 81.7–99.1 | 97.4 | 84.9–99.8 | 19.4 | 5.0–75.3 | 0.0 | 0.0–0.1 | 722.0 | 62.7–8301.8 | 96.2 |
NEFA+BHBA+AST+LCAT+T.CHOL | 97.4 | 86.8–99.5 | 95.0 | 83.5–98.6 | 95.0 | 81.7–99.1 | 97.4 | 84.9–99.8 | 19.4 | 5.0–75.3 | 0.0 | 0.0–0.1 | 722.0 | 62.7–8301.8 | 96.2 |
NEFA+BHBA+AST+LCAT+T.CHOL+PON | 99.7 | 88.4–99.8 | 97.2 | 84.9–99.8 | 97.2 | 84.9–99.8 | 99.7 | 88.4–99.8 | 36.4 | –5.7–230.2 | 0.0 | 0.0–1.2 | 13898.2 | 21.1–9140510.2 | 98.7 |