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Table 1 Rheological characteristics of hydrogels containing hyaluronic acid (HA) and various concentrations of doxycycline (DOX) with Zn 2+ and HA-DOX solutions without Zn 2+

From: Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis

 

G’ (Pa)

G” (Pa)

0.01 Hz

0.1 Hz

0.5 Hz

2.5 Hz

0.01 Hz

0.1 Hz

0.5 Hz

2.5 Hz

HA#

0.020

0.056

0.435

7.056

0.071

0.763

4.160

13.170

Hydrogel 25*

0.055

0.238

1.761

8.473

0.093

0.801

4.749

13.716

Hydrogel 50*

0.052

0.347

2.302

8.574

0.261

0.839

4.910

13.970

Hydrogel 100*

0.338

1.166

2.796

10.363

1.087

2.055

6.492

16.895

Solution 25*

0.001

0.053

1.941

3.721

0.045

0.602

3.846

9.636

Solution 50*

0.004

0.187

1.263

3.969

0.049

0.489

3.160

10.004

Solution 100*

0.003

0.012

1.202

2.750

08.041

0.487

3.691

10.474

  1. Note: 0.5 Hz is the approximate frequency corresponding to the movement of the knee joint in walking; G’, dynamic elastic modulus; G”, dynamic viscous modulus.
  2. Hydrogel, containing 10 mg/mL HA and indicated concentrations of DOX with Zn2+; Solution, containing 10 mg/mL HA and indicated concentrations of DOX without Zn2+.
  3. #Concentration of HA = 10 mg/mL.
  4. *Different concentration of DOX (i.e. 25, 50,100) in μg/mL.
  5. 2.5 Hz is the approximate frequency corresponding to the movement of the knee joint in running.
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BMC Veterinary Research

ISSN: 1746-6148

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