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Table 1 Simulated intravenous administration of ASA (20 mg/kg bodyweight) in the isolated perfused equine distal limb according to Broome et al., 2003

From: Synovial distribution of “systemically” administered acetylsalicylic acid in the isolated perfused equine distal limb

Time (h)

0 - 0.5

0.5 - 1

1 - 2

2 - 3

3 - 4

4 - 5

5 - 6

6 - 7

ASA

μg/mL

100

40

5

0

0

0

0

0

SA

μg/mL

50

125

70

35

20

5

5

5

  1. ASA and SA were added to the perfusion fluid in the respective concentrations indicated below; microdialysis sampling vials were exchanged with every concentration adjustment.