Parameter | Treat1 | Time (minutes) | |||||||
---|---|---|---|---|---|---|---|---|---|
 |  | T0 | T5 | T15 | T20 | T30 | T45 | T60 | T75 |
HR (bpm) | THL | 41 ± 5 | 35 ± 3* | 33 ± 3* | 39 ± 8 | 37 ± 4a | 36 ± 5 | 36 ± 5 | 37 ± 5 |
 | TLL | 39 ± 5 | 35 ± 3* | 34 ± 3* | 34 ± 2* | 34 ± 3*b | 34 ± 3* | 35 ± 3* | 35 ± 3* |
 | TS | 42 ± 4 | 35 ± 4* | 32 ± 2* | 33 ± 2* | 32 ± 3*b | 34 ± 4* | 34 ± 4* | 33 ± 4* |
SAP (mmHg) | THL | - | 138 ± 23 | 154 ± 23* | 155 ± 17* | 158 ± 18* | 176 ± 21* | 179 ± 20* | 175 ± 11*a |
 | TLL | - | 141 ± 26 | 160 ± 28* | 163 ± 29* | 168 ± 28* | 177 ± 30* | 173 ± 22* | 175 ± 19*a |
 | TS | - | 142 ± 24 | 168 ± 40* | 181 ± 42* | 191 ± 43* | 190 ± 34* | 191 ± 26* | 196 ± 24*b |
MAP (mmHg) | THL | - | 109 ± 17 | 120 ± 22* | 123 ± 15* | 125 ± 14* | 139 ± 12* | 146 ± 13* | 146 ± 13* |
 | TLL | - | 113 ± 19 | 126 ± 22* | 129 ± 24* | 132 ± 22* | 139 ± 21* | 140 ± 17* | 144 ± 16* |
 | TS | - | 109 ± 19 | 132 ± 32* | 142 ± 32* | 147 ± 32* | 143 ± 21* | 146 ± 16* | 147 ± 14* |
DAP (mmHg) | THL | - | 92 ± 15 | 101 ± 21 | 105 ± 14* | 108 ± 11* | 118 ± 10* | 124 ± 12* | 128 ± 17* |
 | TLL | - | 96 ± 14 | 106 ± 18* | 110 ± 20* | 113 ± 19* | 117 ± 17* | 120 ± 16* | 124 ± 19* |
 | TS | - | 92 ± 17 | 113 ± 27* | 120 ± 27* | 123 ± 27* | 119 ± 17* | 121 ± 14* | 121 ± 12* |
PaO2 (mmHg) | THL | 99 ± 8 | 266 ± 69* | 294 ± 74* | - | 262 ± 81* | 262 ± 95* | 261 ± 115* | 251 ± 102* |
 | TLL | 92 ± 3 | 315 ± 58* | 319 ± 71* | - | 305 ± 63* | 305 ± 67* | 291 ± 74* | 290 ± 74* |
 | TS | 93 ± 4 | 256 ± 67* | 287 ± 62* | - | 269 ± 61* | 277 ± 70* | 284 ± 70* | 283 ± 75* |
PaCO2 (mmHg) | THL | 41 ± 5 | 55 ± 6* | 51 ± 5* | - | 59 ± 5*a | 55 ± 5* | 57. ± 5*a | 56 ± 5* |
 | TLL | 44 ± 3 | 52 ± 3* | 53 ± 5* | - | 53 ± 4*b | 52 ± 4* | 53 ± 3*b | 54 ± 3* |
 | TS | 43 ± 3 | 52 ± 5* | 53 ± 5* | - | 53 ± 6*b | 52 ± 6* | 53 ± 5*b | 53 ± 6* |
RR (mpm) | THL | 20 ± 7 | 8 ± 3* | 10 ± 3* | 11 ± 5* | 8 ± 2*a | 9 ± 2* | 10 ± 3* | 10 ± 3*a |
 | TLL | 21 ± 4 | 8 ± 2* | 10 ± 3* | 9 ± 1* | 10 ± 3*b | 11 ± 2* | 11 ± 2* | 13 ± 4*ab |
 | TS | 24 ± 7 | 9 ± 2* | 8 ± 2* | 10 ± 2* | 11 ± 3*b | 14 ± 9* | 17 ± 9* | 16 ± 6*b |
pH | THL | 7.40 ± 0.03 | 7.34 ± 0.03* | 7.36 ± 0.02* | - | 7.32 ± 0.02*a | 7.35 ± 0.02* | 7.36 ± 0.02* | 7.36 ± 0.03* |
 | TLL | 7.42 ± 0.01 | 7.36 ± 0.01* | 7.36 ± 0.03* | - | 7.35 ± 0.03*b | 7.37 ± 0.03* | 7.38 ± 0.02* | 7.37 ± 0.02* |
 | TS | 7.42 ± 0.03 | 7.35 ± 0.03* | 7.36 ± 0.03* | - | 7.37 ± 0.04*b | 7.38 ± 0.05* | 7.38 ± 0.04* | 7.39 ± 0.04* |
BE (mmol/L) | THL | 1.5 ± 1.7 | 2.3 ± 1.8 | 2.3 ± 2.3 | - | 2.3 ± 2.4 | 3.6 ± 3.1 | 4.9 ± 2.1* | 4.6 ± 1.9* |
 | TLL | 3.0 ± 1.5 | 2.0 ± 1.0 | 2.9 ± 0.9 | - | 2.4 ± 1.3 | 3.0 ± 0.9 | 4.4 ± 0.4* | 4.8 ± 1.1* |
 | TS | 2.7 ± 1.8 | 2.0 ± 1.4 | 3.2 ± 1.0 | - | 3.8 ± 1.1* | 4.0 ± 1.5* | 4.7 ± 1.2* | 5.2 ± 0.7* |