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Table 1 Experimental groups

From: New aspects on efficient anticoagulation and antiplatelet strategies in sheep

Group

Age

Dose

Loading dose

Testing system

Sheep

Lambs

(bid)

n=

n=

1

a

5

 

500 mg p.o.

 

LTA / BT

 

(7.14–8.33 mg/kg)

 

b

5

 

500 mg i.v.

 

(7.14–8.33 mg/kg)

c

3

 

1 mg/mL 10 mg/mL

 

in vitro

2

a

5

 

150 mg

300 mg

LTA / BT

(2.14–2.5 mg/kg)

(4.29–5.0 mg/kg)

b

5

 

225 mg

450 mg

(3.21–3.75 mg/kg)

(6.43–7.5 mg/kg)

c

5

 

375 mg

600 mg

LTA / BT / clopidogrel / metabolite concentration

(5.36–6.25 mg/kg)

(8.57–10.0 mg/kg)

d

 

5

150 mg

300 mg

(5.0–6.0 mg/kg)

(10.0–12.0 mg/kg)

3

a

5

 

90 mg

180 mg

LTA / BT

(1.29–1.5 mg/kg)

(2.57–3.0 mg/kg)

b

5

 

180 mg

360 mg

(2.57–3.0 mg/kg)

(5.14–6.0 mg/kg)

c

5

 

360 mg

540 mg

(5.14–6.0 mg/kg)

(7.71–9.0 mg/kg)

d

5

 

540 mg

720 mg

(7.71–9.0 mg/kg)

(10.29–12.0 mg/kg)

4

a

5

 

1 mg/kg

2 mg/kg

anti-factor Xa activity

b

5

 

3 mg/kg

 

c

 

5

3 mg/kg

 

d

 

5

5 mg/kg

 

5

 

5

 

600 mg

 

thrombin inhibitor test

(8.57–10.0 mg/kg)

  1. (BT = bleeding time, LTA = light transmission aggregometry, Group 1: acetylsalicylic acid, Group 2: clopidogrel, Group 3: ticagrelor, Group 4: sodium enoxaparin, Group 5: dabigatran etexilate).