From: New aspects on efficient anticoagulation and antiplatelet strategies in sheep
Group | Age | Dose | Loading dose | Testing system | ||
---|---|---|---|---|---|---|
Sheep | Lambs | (bid) | ||||
n= | n= | |||||
1 | a | 5 | Â | 500 mg p.o. | Â | LTA / BT |
 | (7.14–8.33 mg/kg) |  | ||||
b | 5 | Â | 500 mg i.v. | Â | ||
(7.14–8.33 mg/kg) | ||||||
c | 3 | Â | 1 mg/mL 10 mg/mL | Â | in vitro | |
2 | a | 5 | Â | 150 mg | 300 mg | LTA / BT |
(2.14–2.5 mg/kg) | (4.29–5.0 mg/kg) | |||||
b | 5 | Â | 225 mg | 450 mg | ||
(3.21–3.75 mg/kg) | (6.43–7.5 mg/kg) | |||||
c | 5 | Â | 375 mg | 600 mg | LTA / BT / clopidogrel / metabolite concentration | |
(5.36–6.25 mg/kg) | (8.57–10.0 mg/kg) | |||||
d | Â | 5 | 150 mg | 300 mg | ||
(5.0–6.0 mg/kg) | (10.0–12.0 mg/kg) | |||||
3 | a | 5 | Â | 90 mg | 180 mg | LTA / BT |
(1.29–1.5 mg/kg) | (2.57–3.0 mg/kg) | |||||
b | 5 | Â | 180 mg | 360 mg | ||
(2.57–3.0 mg/kg) | (5.14–6.0 mg/kg) | |||||
c | 5 | Â | 360 mg | 540 mg | ||
(5.14–6.0 mg/kg) | (7.71–9.0 mg/kg) | |||||
d | 5 | Â | 540 mg | 720 mg | ||
(7.71–9.0 mg/kg) | (10.29–12.0 mg/kg) | |||||
4 | a | 5 | Â | 1 mg/kg | 2 mg/kg | anti-factor Xa activity |
b | 5 | Â | 3 mg/kg | Â | ||
c | Â | 5 | 3 mg/kg | Â | ||
d | Â | 5 | 5 mg/kg | Â | ||
5 | Â | 5 | Â | 600 mg | Â | thrombin inhibitor test |
(8.57–10.0 mg/kg) |