Figure 6

Anti-factor Xa activity of lambs compared to sheep after administration of sodium enoxaparin. Highly significant differences in the anti-FXa activity were observed administering the same concentration (3 mg/kg bid) of sodium enoxaparin to lambs (Group 4c) and to sheep (Group 4b) (day 1: p = 0.008 independent t-Test, day 4: p = 0.008 independent t-Test, day 7: p = 0.016 Mann–Whitney U-Test). The treatment of lambs with 3 mg/kg bid induced no significant increase between reference values and days 1, 4 and 7 (Friedman Test, post hoc Wilcoxon Signed Rank Test). However, anti-factor Xa concentrations in the human therapeutic range (0.60–1.0 IU/mL) could be reached administering 5 mg/kg sodium enoxaparin bid to lambs. These data are comparable to Group 4b (sheep, 3 mg/kg bid) without any significant differences (two-way repeated measures ANOVA). In these two groups, there was a highly significant increase comparing reference values with days 1, 4 and 7, respectively (p ≤ 0.01, one-way repeated measures ANOVA).