Figure 4
From: New aspects on efficient anticoagulation and antiplatelet strategies in sheep
Light transmission aggregometry after administration of ticagrelor (Group 3d). Platelet aggregation was induced by adenosine diphosphate in a concentration of 2 × 10-5 M. Regarding the platelet final aggregation (time point 10 minutes) on day 7 with ticagrelor in a dosage of 540 mg bid, an inhibition below the cut-off value (red line, 64.2%) could only be noticed in Sheep 3 (final aggregation: 55%). The other sheep showed no response, with line profiles almost equal and platelet aggregation values ranging from 82–98%. Calculating the results of all sheep, no significant differences could be noticed between baseline, days 1, 4 or 7 (one-way repeated measures ANOVA).