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Figure 3 | BMC Veterinary Research

Figure 3

From: New aspects on efficient anticoagulation and antiplatelet strategies in sheep

Figure 3

Clopidogrel and clopidogrel metabolite could be detected in every plasma sample in sheep and lambs. Both clopidogrel and its main inactive metabolite clopidogrel carboxylic acid could be measured in each plasma sample during the 7-day treatment with 375 mg (5.36–6.25 mg/kg, sheep) and 150 mg (5.0–6.0 mg/kg, lambs) bid. A significant and highly significant increase in the metabolite plasma concentration between baseline and measurement time points in sheep (blue bars) and in lambs (green bars) could be observed (one-way repeated measures ANOVA). There were significant and highly significant differences concerning the metabolite concentration between sheep and lambs (day 1: p = 0.031, day 4: p = 0.011, day 7: p = 0.005, independent t-Test, post hoc Bonferroni Test). The animal's age had a highly significant influence on the concentration of the metabolite (p = 0.004, two-way repeated measures ANOVA). In sheep and lambs, clopidogrel could be detected in each sample on days 1, 4, 7 and 28, respectively. However, there was no significant difference between the measurement time points in sheep (one-way repeated measures ANOVA) and in lambs (Friedman Test, post hoc Wilcoxon Signed Rank Test). Values among sheep and lambs differed markedly. No significant differences in clopidogrel plasma concentration could be detected between sheep and lambs (independent t-Test, Mann–Whitney U-Test).

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