Figure 2

Clopidogrel inhibited platelet final aggregation adequately in 2 out of 5 sheep (Group 2). A: Calculated light transmission aggregometry (LTA) results of all sheep receiving clopidogrel per os in a dosage of 150 mg (grey bars, Group 2a), 225 mg (blue bars, Group 2b) and 375 mg (green bars, Group 2c) bid (mean ± SD). Platelet aggregation was induced by 2 × 10^-5 M adenosine diphosphate (ADP). No significant inhibition of platelet final aggregation could be measured in LTA (Friedman Test, one-way repeated measures ANOVA). In Group 2c (green bars) values declined just below the cut-off value (red line, 64.2%). B–C: Platelet final aggregation of Sheep 1 (B) was not inhibited by administration of 150 mg clopidogrel bid. Increasing the dosage up to 225 mg (blue bars Group 2b) or 375 mg (green bars, Group 2c) bid, values on day 7 declined below the cut-off value (red line, 64.2%). By contrast, in Sheep 3 (C) an adequate effect of clopidogrel in every dosage can be seen on days 4 and 7 (values below the cut-off value).