Figure 6

Close correlation between damaged and replicative fractions in tendon fibroblast monolayers is uncoupled on fibronectin. The percentages of damaged (black) and replicating (grey) cells are shown in monolayers with low (1), intermediate (2), or high replicative fractions (3) on both collagen and fibronectin surfaces. Each group comprises 5 data points collected from a different source animal. The ages of these animals were, from left to right: 6 months, 3, 5, 14 and 15 years. A close association of the two fractions can be seen on collagen, but on fibronectin the damage level remains relatively high regardless of confluence status i.e. there is an uncoupling of these two events.