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Table 2 Efficacy end-points

From: Concurrent short-term use of prednisolone with cyclosporine A accelerates pruritus reduction and improvement in clinical scoring in dogs with atopic dermatitis

Assessment

Type of assessment

Criteria

Owner assessments

Pruritus (Primary endpoint)

Pruritus VAS

0 = “my dog is not itchy: no scratching, chewing, rubbing or licking observed”

100 = “my dog is extremely itchy: scratching, chewing, rubbing or licking constantly”

Individual pruritus observations on VAS at any time were expressed as a percentage:

VAS_P = 100% × VAS length / total length of scale[13]

Overall assessment of clinical response

Score

[0] Poor: My dog’s dermatological condition has deteriorated or not changed compared to before treatment.

[1] Moderate: My dog’s dermatological condition has only slightly improved compared to before treatment.

[2] Good: My dog’s dermatological condition has clearly improved compared to before treatment.

[3] Excellent: My dog’s dermatological condition has completely recovered as compared to before treatment.

Clinical assessments

Overall assessment of clinical response

Score

[0] Poor: worsening or no change of the clinical signs of the atopic dermatitis as compared to initial examination.

[1] Moderate: slight amelioration of the clinical signs of the atopic dermatitis as compared to initial examination.

[2] Good: clear amelioration of the clinical signs of the atopic dermatitis as compared to initial examination.

[3] Excellent: Clinical signs of the atopic dermatitis observed during the first examination have completely disappeareds.

CADESI-03

Score

Completion of validated template grading erythema, lichenification, excoriations, alopecia and the sum score for all four lesions at 62 body sites (grades, none: 0; 1: mild; 2, 3: moderate; 4, 5: severe) [13].