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Table 1 D-dimer formation during thromboylsis of in vitro generated equine thrombi (n = 4 horses for 0.5, 3.5 and 5 μg/ ml rt-PA, n =  7 for 0 and 1.5 μg/ ml rt-PA, all thrombi for each time point and concentration were performed at least in triplicates)

From: Pharmacokinetics and thrombolytic effects of the recombinant tissue-type plasminogen activator in horses

t-PA (μg/ml)

0 h

1 h

2 h

3 h

4 h

0

0.10 (± 0.00)

0.10 (± 0.01)

0.10 (± 0.01)

0.11 (± 0.04)

0.11 (± 0.03)

0.5

0.12 (± 0.03)

1.83 (± 0.76)

4.40 (± 1.49)

7.72 (± 3.28)

10.08 (± 3.70)

1.5

0.11 (± 0.03)

4.74 (± 2.55)

8.08 (± 4.97)

9.25 (± 4.35)

9.78 (± 4.87)

3.5

0.12 (± 0.03)

1.87 (± 0.74)

2.70 (± 0.99)

4.14 (± 1.97)

4.64 (± 2.22)

5

0.12 (± 0.03)

1.77 (± 0.55)

2.98 (± 0.84)

4.22 (± 1.67)

5.32 (± 2.44)