Table 2 Pharmacokinetic parameters of buprenorphine after 0.0075 mg/kg bwt intravenously in ten horses
Horse | λz(h-1) | T1/2λ(h) | Vd(L/kg) | Cl (mL/min/kg) | AUC0-∞(h·ng/mL) | MRT (h) |
|---|---|---|---|---|---|---|
1 | 0.12 | 7.02 | 3.89 | 6.40 | 19.54 | 6.98 |
2 | 0.06 | 12.09 | 1.88 | 1.80 | 69.39 | 12.48 |
3 | 0.06 | 8.86 | 2.90 | 3.78 | 33.12 | 9.25 |
4 | 0.12 | 5.59 | 0.83 | 1.71 | 72.93 | 5.12 |
5 | 0.12 | 6.79 | 1.03 | 1.76 | 71.17 | 6.54 |
6 | 0.18 | 3.51 | 0.56 | 1.84 | 67.91 | 3.47 |
7 | 0.06 | 9.89 | 3.07 | 3.59 | 34.81 | 11.96 |
8 | 0.12 | 6.85 | 0.92 | 1.56 | 80.33 | 7.61 |
9 | 0.18 | 4.30 | 1.69 | 4.55 | 27.47 | 5.09 |
10 | 0.12 | 7.47 | 3.74 | 5.78 | 21.62 | 9.56 |
Mean ± SD | 0.11 ± 0.04 | 6.4 ± 2.63* | 2.05 ± 1.25 | 3.28 ± 1.82 | 49.83 ± 24.37 | 7.81 ± 2.98 |