Table 4 Semiquantitative scoring systems for murine central nervous disease models

Ischemic neuronal damage (0–3)

2176

18 areas x neuronal injury (0–5)

23

Infarcts in 3 cerebral regions (0–4), hippocampus infarction (0–4)

100

Eight regions x neuronal cell los/gliosis/iron deposition/gliosis (0–3)

95

Edema, fiber regeneration (each 0–4)

21

Inflammation, neuronal degeneration (each 0–4)

160

Inflammation (cells/cuff), axonal injury, axonal loss (each 0–4)

81

Lesion severity, myelin loss/tissue injury, acute inflammation, chronic inflammation (each 0–5)

79

Neuropil inflammation, demyelination, necrosis, meningeal inflammation (each 0–4)

77

Infiltration, demyelination (together 0,1) in 16 regions

64

Inflammation, necrosis (each 0–3)

53

Inflammation (cuffs/100 m²), demyelination (lesions/mm²)

52

Meningitis (0–2), perivascular cuffing (0–5), demyelination (0–3)

43

Spinal cord demyelination (0–3), inflammatory cells (No./mm²)

22

Gray matter degeneration/infarction (0–4) in 5 μm serial sections

33

150 μm intervals x Area affected by neuronal degeneration, malacia (0–4)

23

Meningeal inflammation (0–3) x four regions

46

Meningitis, perivascular cuffing, neuropil infiltration (each 0–4)

41

7 areas x necrosis (0–3)

27

Spongiosis (0–3), lipofuscin positive cells (%)

23

Molecular layer thickness, Purkinje cell loss (each 0–3)

10