Variable | Univariate | Multivariable* | ||||
---|---|---|---|---|---|---|
Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P | |
Tumour size | ||||||
< 3 cm | Referent | |||||
≥ 3 cm | 2.79 | 1.16-6.68 | 0.022 | NS | ||
Mode of growth | ||||||
Expansive | Referent | |||||
Invasive | 4.63 | 1.08-19.85 | 0.039 | NS | ||
Histological type | ||||||
Complex carcinomas | Referent | |||||
Simple carcinomas | 2.75 | 0.62-12.17 | NS | |||
Others | 6.48 | 1.34-31.22 | 0.020 | NS | ||
Histological grade | ||||||
I + II | Referent | |||||
III | 2.52 | 1.09-5.82 | 0.031 | NS | ||
MIB1 L.I. (%) | ||||||
< 40 | Referent | Referent | ||||
≥ 40 | 4.60 | 1.79-11.85 | 0.002 | 4.06 | 1.56-10.58 | 0.004 |
uPA (%) | ||||||
< 10 | Referent | |||||
≥ 10 | 5.28 | 1.23-22.60 | 0.025 | NS | ||
MMP-9 (%) | ||||||
< 50 | Referent | Referent | ||||
≥ 50 | 4.21 | 1.76-1.09 | 0.001 | 3.67 | 1.52-8.89 | 0.004 |