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Figure 3 | BMC Veterinary Research

Figure 3

From: RACK1, a clue to the diagnosis of cutaneous melanomas in horses

Figure 3

RACK1 and MITF immunolabelings in cutaneous melanocytic proliferations from horses. MITF labeling is shown in red and RACK1 in green. (A) melanocytoma, (B) melanoma, (C) achromic melanoma. In melanocytoma, RACK1 cytoplasmic expression is heterogeneous (A1 and A2). Arrowheads point to melanocytic cells that express variable amounts of RACK1. By contrast, in pigmented or achromic melanoma (B1 to C2), all MITF-positive cells display a strong and homogeneous cytoplasmic RACK1 signal (B2, C2). Nuclear counterstaining is shown in blue. Corresponding bright-field photographs are presented (A3 to C3). Magnification is the same in all images, scale bar represents 10 μm.

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