Group | Composition | Dose | Administration | ||
---|---|---|---|---|---|
I | Mock control | ||||
II | Control+Melatonin implant | ||||
III | Vaccine | 2 mL | subcutaneus | ||
IV | Vaccine+Melatonin implant | 2 mL | subcutaneus | ||
Day | 0 | 21 | 42 | 60 | 90 |
Vaccination | + | + | |||
Melatonin implant | + | + | |||
Blood collection | + | + | + | + | + |
Platelet function | + | + | + | + | + |
Melatonin measurement | + | + | + | + | + |
Rectal temperature | + | + | |||
Local reaction | + | + | |||
General reaction | + | + |