Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep

Table 2 Serum antibody levels at the different treatments

Treatment			Day
Treatment	0	21	42	60	90
I. Control	13 ± 2	12 ± 3	14 ± 3	16 ± 4	15 ± 3
II. Melatonin Implant	12 ± 2	16 ± 3	14 ± 4	13 ± 3	15 ± 2
III. Vaccine	16 ± 3	40 ± 6^*†	90 ± 5^*†	104 ± 4^*†	70 ± 5^*†
IV. Vaccine + Melatonin Implant	14 ± 3	52 ± 5^*†§†	112 ± 6^*†§†	141 ± 5^*†§†	97 ± 4^*†§†

Values represent mean antibodies levels as determined by microagglutination assays. Data are presented as mean ± S.E.M. of 10 experiments. ^*P < 0.05 compared with day 0. ^†P < 0.05 compared with their respective control in nonvaccinated animals. ^§P < 0.05 compared with the application of melatonin implants. ^†P < 0.05 compared with vaccinated animals.

ISSN: 1746-6148