Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep

Table 1 Plasma melatonin concentration (pg/mL) at the time of the vaccination procedure at 10:00 A.M

Treatment			Day
Treatment	0	21	42	60	90
I. Control	123 ± 10	132 ± 12	127 ± 12	131 ± 8	126 ± 10
II. Melatonin Implant	125 ± 10	277 ± 14^*†	296 ± 15^*†	292 ± 12^*†	261 ± 10
III. Vaccine	120 ± 14	126 ± 10	124 ± 12	128 ± 12	130 ± 10
IV. Vaccine+Melatonin Implant	126 ± 12	295 ± 11^*†	328 ± 13^*†	313 ± 9^*†	287 ± 14^*†

Values represent mean melatonin concentration as determined by enzyme-linked immunosorbent assay (ELISA). Data are expressed as pg/mL and presented as mean ± S.E.M. of 10 experiments. ^*P < 0.05 compared with day 0. ^†P < 0.05 compared with their respective control in non-vaccinated animals.

ISSN: 1746-6148