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Table 1 Evaluation of the aqueous solubility (μg/mL, n = 6) of different benzimidazole (BZD) compounds with or without hydroxypropyl-ß-cyclodextrin (HPßCD) (10%) at different pHs (1.2 or 7.4)

From: Exploring flubendazole formulations for use in sheep. Pharmacokinetic evaluation of a cyclodextrin-based solution

BZD compound

pH 1.2

pH 7.4

With HPßCD

Without HPßCD

With HPßCD

Without HPßCD

Albendazole

921.1 ± 347.3

406.1 ± 53.4*

43.0 ± 8.3

4.6 ± 1.3*

Albendazole sulphoxide

6637.7 ± 1370.2

3818.6 ± 202.1*

871.9 ± 129.3

83.6 ± 7.6*

Mebendazole

436.7 ± 47.4

20.5 ± 5.0*

43.0 ± 8.3

4.6 ± 1.3*

Oxfendazole

1902.5 ± 605.8

419.7 ± 29.2*

348.1 ± 46.8

5,5 ± 1.1*

Flubendazole

2251.7 ± 551.5

29.6 ± 2.8*

163.8 ± 119.7

5.8 ± 7.0*

  1. *At each pH value (1.2 or 7.4), significantly different from the solubility obtained in the presence of HPßCD at P < 0.05.
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BMC Veterinary Research

ISSN: 1746-6148

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