Table 3 Differentially expressed genes in PPC + S group involved in immune and inflammatory responses (mean fold change of PPC control group levels)

Inflammatory mediators and transducers

Interleukin-22

10.35 ± 3.67

Interleukin-18

2.66 ± 0.84

Chemokine CK-1

4.75 ± 0.99

C-C motif chemokine 19-1

3.73 ± 1.12

Suppressor of cytokine signaling 1

2.68 ± 0.33

C-C chemokine receptor type 9

2.57 ± 0.68

C-C motif chemokine 21

−1.95 ± 0.30

Interleukin-6 receptor subunit alpha

2.73 ± 0.98

Interleukin-1 receptor type II

2.07 ± 0.30

Interleukin-1 receptor antagonist

1.65 ± 0.09

Arachidonate 5-lipoxygenase-activating protein

3.49 ± 0.91

Leukotriene b4 12-hydroxydehydrogenase

2.43 ± 0.40

Annexin A1

11.46 ± 5.46

Annexin A2-A

2.13 ± 0.20

Annexin A5

2.39 ± 0.33

TNF decoy receptor

5.37 ± 1.26

TNF receptor superfamily member 5

1.83 ± 0.21

TNFalpha-induced protein 8-like protein 2

1.78 ± 0.21

NF-kappa-B p100 subunit

2.14 ± 0.07

NF-kappa-B inhibitor alpha

1.71 ± 0.03

NF-kappa-B inhibitor epsilon

1.96 ± 0.14

CCAAT/enhancer binding protein beta-2

3.00 ± 0.98

Transcription factor AP-1

1.67 ± 0.20

Transcription factor jun-B

2.16 ± 0.32

IFN-dependent

MHC class I antigen

−4.27 ± 0.95

MHC class I

−5.42 ± 0.16

MHC class Ia heavy chain

−3.76 ± 1.56

Beta-2 microglobulin

−2.27 ± 0.52

Tyrosine-protein kinase Jak1

2.14 ± 0.26

Similar to very large inducible GTPase 1

−5.81 ± 1.54

Receptor-transporting protein 3

−3.52 ± 0.91

Gamma-interferon-inducible thiol reductase

−2.67 ± 0.65

Interferon-induced protein 44

−2.48 ± 0.39

Fish virus induced TRIM protein

−2.12 ± 0.37

SRK2 tyrosine kinase

−1.89 ± 0.24

Galectin-3-binding protein

−1.74 ± 0.22

Effectors: complement and lectins, antimicrobial proteins

FBPL4 (lectin)

7.46 ± 2.29

Precerebellin-like protein (lectin)

8.58 ± 4.27

Complement factor D

4.46 ± 1.93

Complement C1q-like protein 2

3.34 ± 1.41

Complement C1q-like protein 4

2.26 ± 0.59

C5a anaphylatoxin chemotactic receptor

2.34 ± 0.61

Complement component C6

2.45 ± 0.65

Properdin P factor 2

1.76 ± 0.17

C1 inhibitor

−5.25 ± 1.31

C4b-binding protein alpha chain

−1.77 ± 0.16

Nattectin

5.97 ± 2.21

Cathelicidin

7.08 ± 3.32

High affinity IG epsilon receptor gamma

3.32 ± 1.16

High affinity IG gamma Fc receptor I

1.85 ± 0.11

Differentially regulated trout protein 1

3.39 ± 1.28

C type lectin receptor A

2.20 ± 0.48

Proteases and inhibitors, T-cells

E3 ubiquitin-protein ligase LINCR

18.11 ± 1.38

Matrix metalloproteinase-9

3.56 ± 1.34

Collagenase 3

4.38 ± 1.74

Matrix metalloproteinase

2.97 ± 1.03

E74-like factor 3

2.78 ± 0.31

Metalloproteinase inhibitor 2

4.67 ± 1.44

Leukocyte elastase inhibitor

1.75 ± 0.06

T-cell receptor beta chain T17T-22

6.73 ± 1.91

T-cell immunoglobulin and mucin domain-containing 4

2.30 ± 0.51

CD86

1.90 ± 0.24

CTLA4-like protein

2.04 ± 0.22

Oxidative burst, protection against free radicals

Myeloperoxidase

32.43 ± 4.77

Cytochrome b558 alpha-subunit

7.06 ± 1.86

Cytochrome b-245, beta polypeptide

3.08 ± 1.12

Neutrophil cytosolic factor 1

7.19 ± 3.88

Arginase-2, mitochondrial

14.78 ± 2.87

Ornithine decarboxylase 1

1.76 ± 0.26

Nitric oxide synthase trafficker

−1.67 ± 0.25

Glutathione reductase, mitochondrial

2.30 ± 0.34

Glutathione peroxidase 4b

−2.05 ± 0.12

Glutathione S-transferase alpha 3

−2.63 ± 0.36

Glutathione S-transferase kappa 1-like

−1.88 ± 0.25

Glutathione S-transferase P

−2.72 ± 0.67

Glutathione transferase zeta 1 isoform 1

−1.96 ± 0.12

Peroxiredoxin-4

−1.69 ± 0.14

Catalase

−2.47 ± 0.05

Arrestin domain-containing protein 2

−2.59 ± 0.13

CDGSH iron sulfur domain-containing protein 1

−2.50 ± 0.32

Peptide methionine sulfoxide reductase

−1.77 ± 0.21

5-aminolevulinate synthase, nonspecific, mitochondrial

3.54 ± 0.46

Metallothionein A

−6.46 ± 0.95

Heme oxygenase

−6.58 ± 1.78

Heme-binding protein 2

−2.89 ± 0.44

Ferritin, middle subunit

−3.03 ± 0.26

High affinity copper uptake protein 1

−2.62 ± 0.52

Copper transport protein ATOX1

−3.41 ± 0.80