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Table 1 Viral excretion and humoral response after intranasal infection. Detection of viral DNA in trigeminal ganglia (TG)

From: In vitro-generated interspecific recombinants between bovine herpesviruses 1 and 5 show attenuated replication characteristics and establish latency in the natural host

 

Acute phase

 

Latent phase

Humoral response

Group

Nasal excretiona

Days post infection of excretion onset

N° excreting days

Viral DNA in TGb

Mucosal IgAc

Seroconversiond

BHV-5 N569

3/4

2-7

4-10

2/4

3/4

3/4

BHV-1.2 ΔgCΔgI

1/4

5*

1

2/3

4/4

0/4

R1ΔgC

2/4

2-3

1

2/4

3/4

1/4

R2ΔgI

1/4

1*

1

1/4

1/4

0/4

Mock-infected

0/2

0

0

0/2

0/2

0/2

  1. * Positive samples after 2-3 blind passages in cell culture.
  2. a Number of excreting animals out of total animals in the group. Identity of excreted virus was confirmed by PCR and fluorescence microscopy.
  3. b Number of trigeminal ganglia (TG) with viral DNA out of total TG available.
  4. c Mucosal IgA raised toward BoHV-1/-5. Number of positive animals out of total animals in the group.
  5. d Serum antibodies against BoHV-1/-5. Number of positive animals out of total animals in the group.