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Figure 1 | BMC Veterinary Research

Figure 1

From: In vitro-generated interspecific recombinants between bovine herpesviruses 1 and 5 show attenuated replication characteristics and establish latency in the natural host

Figure 1

Representation of the genetic background of the four viruses inoculated in this study. Parental strains: wild-type BoHV-5 (N569 strain) and mutant BoHV-1ΔgCΔgI; interspecific recombinants: R1ΔgC and R2ΔgI. The organization of the four genomes includes a unique long (UL) and a unique short (US) sequence. The latter is flanked by two repeated and inverted sequences (internal repeat, IR; terminal repeat, TR). The parental BoHV-1 is a mutated strain in which the genes encoding the glycoproteins gC (UL44) and gI (US7) were replaced by sequences encoding fluorescent proteins GFP and RFP respectively (labeled by large asterisks). The BoHV-5 and BoHV-1 sequences are represented by black or white lines and rectangles respectively. The site of recombination in each recombinant virus is represented by discontinuous lines.

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