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Table 2 List of the 15 biomarkers that were differentially expressed in scrapie sheep in comparison to control animals

From: Ovine serum biomarkers of early and late phase scrapie

Markers

Mass (Da)

Fraction

Variation

Healthy (n = 65) vsEP (n = 55)

Healthy (n = 65) vsLP (n = 43)

    

FDR (%)

SAM

FC

AUC

FDR (%)

SAM

FC

AUC

S1

4030

F4

over

0,00

4,72

1,81

0,771

13,01

1,44

1,44

0,617

S2

4250

F1

under

0,00

-3,56

0,53

0,735

ND

ND

ND

ND

S3

7475

F3

over

0,00

3,39

1,75

0,741

ND

ND

ND

ND

S4

9395

F3

over

0,00

4,21

1,89

0,717

ND

ND

ND

ND

S5

3895

F6

under

ND

ND

ND

ND

15,34

-1,99

0,38

0,702

S6

7690

F6

over

ND

ND

ND

ND

0,00

2,31

1,26

0,659

S7

9425

F6

over

ND

ND

ND

ND

0,00

3,07

1,49

0,693

S8

27450

F6

over

ND

ND

ND

ND

4,77

2,20

1,39

0,672

S9

13670

F5

over

ND

ND

ND

ND

0,00

3,15

1,39

0,683

S10

12030

F6

under

ND

ND

ND

ND

10,74

-2,91

0,79

0,625

S11

8350

F6

over

ND

ND

ND

ND

4,77

2,12

1,19

0,648

S12

7555

F1

over

ND

ND

ND

ND

0,00

2,63

1,16

0,648

S13

4575

F3

over

0,00

3,42

1,38

0,668

0,00

2,83

1,18

0,671

S14

9180

F3

over

0,00

3,98

2,00

0,707

ND

ND

ND

ND

S15

6815

F4

under

3,34

-2,40

0,81

0,637

ND

ND

ND

ND

  1. These peaks were selected according to their False Discovery Rate (FDR), their Fold Change (FC), their AUC ROC and the SAM test. The peak S1 and S13 were significant both in EP and LP; S2, S3, S4, S14 and S15 were significant in EP; S5, S6, S7, S8, S9, S10, S11 and S12 were significant in LP. ND: Non determined, only for non significant values.