BMC Veterinary Research

Table 4 Effect of test substances on packed cell volume (PCV) of Trypanosma congolense infected mice

From: Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolensefield isolate

Treatment	Dose (mg/kg)	PCV/Day of treatment
Treatment	Dose (mg/kg)	PCV0	PCV7	PCV14
Exudate	100	47.10 ± 0.68	42.40 ± 1.07^bc	45.10 ± 0.91^a
	200	48.30 ± 1.11	44.00 ± 1.50^b	48.20 ± 0,46^a
	400	47.00 ± 1.21	43.60 ± 1.41^b	47.60 ± 1.44^a
Aloin	100	46.40 ± 1.53	40.00 ± 1.87^bc	42.70 ± 1.21^bc
	200	46.00 ± 1.17	40.60 ± 1.22^bc	43.90 ± 0.66^bc
	400	45.50 ± 1.50	41.70 ± 1.21^bc	46.20 ± 1.34^a
Aloe-emodin	100	50.20 ± 1.20	44.20 ± 1.65^b	47.20 ± 0.73^a
	200	47.90 ± 0.60	44.30 ± 0.80^b	46.10 ± 0.87^a
	400	47.10 ± 0.57	45.90 ± 1.45^b	47.30 ± 0.73^a
Rhein	100	47.10 ± 0.64	45.40 ± 0.76^b	47.20 ± 0.25^a
	200	50.00 ± 0.65	45.80 ± 0.46^b	49.30 ± 0.41^a
	400	50.20 ± 1,10	48.00 ± 1.15	50.40 ± 0.73^a
Diminazene aceturate	28	50.10 ± 0.33	48.60 ± 0.57	50.60 ± 0.43^a
Distilled water	0.1 ml	46.00 ± 0.79	42.10 ± 1.18^bc	40.10 ± 1.10^*
Uninfected untreated	_	50.50 ± 0.59	51.10 ± 0.66	50.80 ± 0.67

Values are Mean ± SEM, N = 6, D = day, PCV0 = PCV on the day treatment commenced, SEM = standard error of mean. All superscripts indicate significance at P < 0.05 (^aagainst negative control, ^bagainst uninfected-untreated, ^cagainst 28 mg/kg diminazene aceturate, ^*against all groups), PCV was compared with each other mainly at days 7 and 14.

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ISSN: 1746-6148

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