Table 3 Adapted international uniform response criteria for multiple myeloma

Stringent Complete Response (sCR)

Normalization of paraprotein

Disappearance of any soft-tissue plasmacytomas

<5% plasma cells in bone marrow

Absence of clonal cells in bone marrow by PARR

Complete Response (CR)

Same as above, without clonality criterion

Partial Response (PR)

>50% reduction in paraprotein from baseline

>50% reduction in bone marrow plasma cells

>50% reduction in soft-tissue plasmacytomas, if present

Stable Disease (SD)

Not meeting criteria for CR, PR or PD

Progressive Disease (PD)

Increase of 25% from lowest response value in:

Serum paraprotein

Bone marrow plasma cell percentage (exceeding 10%)

Definite development of new bone or soft-tissue lesions

Definite increase in size of existing bone or soft-tissue lesions

Development of hypercalcemia not attributable to another cause